T-bet deficiency decreases susceptibility to experimental myasthenia gravis.

Abstract

T-bet, a tissue-specific transcription factor, controls T helper 1 (Th1) cell differentiation and IFN-production. Given the reciprocal relationship between Th1 and other types of helper T cells, we hypothesized that T-bet impacts multiple helper and regulatory T (Treg) cells, thereby influencing the magnitude of autoimmune disease. We tested this hypothesis… (More)
DOI: 10.1016/j.expneurol.2009.09.022

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@article{Liu2009TbetDD, title={T-bet deficiency decreases susceptibility to experimental myasthenia gravis.}, author={Ruolan Liu and Junwei Hao and Carlos S Dayao and F. Shi and Denise Campagnolo}, journal={Experimental neurology}, year={2009}, volume={220 2}, pages={366-73} }