T-bet: a bridge between innate and adaptive immunity

  title={T-bet: a bridge between innate and adaptive immunity},
  author={Vanja Lazarevic and L. H. Glimcher and Graham M Lord},
  journal={Nature Reviews Immunology},
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across… CONTINUE READING
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