T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

@inproceedings{Liu2017TbetCD11cBC,
  title={T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus},
  author={Ya Liu and Shiyu Zhou and Jie Qian and Yan Wang and Xiang Yu and Dai Dai and Min Dai and Lingling Wu and Zhuojun Liao and Zhixin Xue and Jiehua Wang and Goujun Hou and Jianyang Ma and John Barker Harley and Yuanjia Tang and Nan Shen},
  booktitle={Arthritis research & therapy},
  year={2017}
}
BACKGROUND A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c+ B cells in the development of lupus is unclear. Chronic graft-versus-host disease (cGVHD) is a lupus-like syndrome with high autoantibody production. The purpose of this study was to explore the role of CD11c+ B cells in the pathogenesis of lupus in cGVHD… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 56 references

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha

  • NS Wang, LJ McHeyzer-Williams, SL Okitsu, TP Burris, SL Reiner, MG. McHeyzerWilliams
  • Nat Immunol
  • 2012
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