T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus.


Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of approximately 80% of human Merkel cell carcinomas (MCCs). Transcript mapping was performed to show that MCV expresses transcripts in MCCs similar to large T (LT), small T (ST), and 17kT transcripts of SV40… (More)
DOI: 10.1073/pnas.0806526105

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