T-Wave Alternans and Arrhythmogenesis in Cardiac Diseases

  title={T-Wave Alternans and Arrhythmogenesis in Cardiac Diseases},
  author={Zhilin Qu and Yuanfang Xie and Alan Garfinkel and James N. Weiss},
  booktitle={Front. Physio.},
T-wave alternans, a manifestation of repolarization alternans at the cellular level, is associated with lethal cardiac arrhythmias and sudden cardiac death. At the cellular level, several mechanisms can produce repolarization alternans, including: 1) electrical restitution resulting from collective ion channel recovery, which usually occurs at fast heart rates but can also occur at normal heart rates when action potential is prolonged resulting in a short diastolic interval; 2) the transient… CONTINUE READING


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