T Helper1/T Helper2 Cells and Resistance/Susceptibility to Leishmania Infection: Is This Paradigm Still Relevant?

@inproceedings{Alexander2012THH,
  title={T Helper1/T Helper2 Cells and Resistance/Susceptibility to Leishmania Infection: Is This Paradigm Still Relevant?},
  author={J. -P. Alexander and Frank Brombacher},
  booktitle={Front. Immun.},
  year={2012}
}
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4(+) T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4(-/-) mice in the 1990s questioned the paramount role of this Th2 archetypal cytokine in the non-healing response to Leishmania infection. The more recent characterization of CD4(+) T cell regulatory populations and further effector CD4(+) T… CONTINUE READING
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