T-Coffee: A novel method for fast and accurate multiple sequence alignment.

@article{Notredame2000TCoffeeAN,
  title={T-Coffee: A novel method for fast and accurate multiple sequence alignment.},
  author={C{\'e}dric Notredame and Desmond G. Higgins and Jaap Heringa},
  journal={Journal of molecular biology},
  year={2000},
  volume={302 1},
  pages={205-17}
}
We describe a new method (T-Coffee) for multiple sequence alignment that provides a dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most commonly used alternatives. The method is broadly based on the popular progressive approach to multiple alignment but avoids the most serious pitfalls caused by the greedy nature of this algorithm. With T-Coffee we pre-process a data set of all pair-wise alignments between the sequences. This provides us with a library of… CONTINUE READING
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