T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD

@article{Haag2002TCO,
  title={T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD},
  author={Friedrich Haag and Dunja Freese and Felix Scheublein and Wiebke Ohlrogge and Sahil Adriouch and Michel Seman and Friedrich Koch-Nolte},
  journal={Developmental Immunology},
  year={2002},
  volume={9},
  pages={197 - 202}
}
Extracellular nucleotides such as ATP and NAD can profoundly affect the functions of lymphocytes, macrophages, and other cells. We have recently shown that extracellular NAD induces rapid apoptosis in naive T cells by a mechanism involving the ADP-ribosylation of cell surface molecules. In the present paper, we describe that T cells of different developmental stages differ in their sensitivity to NAD-induced apoptosis. Thymocytes were less susceptible than peripheral lymph node T cells, and… CONTINUE READING
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