T Cells and Tuberculosis: Beyond Interferon-gamma.

  title={T Cells and Tuberculosis: Beyond Interferon-gamma.},
  author={Ajit Lalvani and Kerry A. Millington},
  journal={The Journal of infectious diseases},
  volume={197 7},
The cytokine interferon(IFN) plays a pivotal role in protective immunity against intracellular pathogens. Specifically, in Mycobacterium tuberculosis (MTB) infection, IFNis an important mediator of macrophage activation [1]. Mice deficient in the gene for IFNare susceptible to fatal tuberculosis (TB) [1, 2], and humans deficient in either the gene for IFNor the IFNreceptor show enhanced susceptibility to mycobacterial infections [3]. Measurement of the IFNresponse to MTB infection has been… CONTINUE READING


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