T-Cell Transfer Therapy Targeting Mutant KRAS.

  title={T-Cell Transfer Therapy Targeting Mutant KRAS.},
  author={Steven A Rosenberg and Eric Tran and Paul F. Robbins},
  journal={The New England journal of medicine},
  volume={376 7},
To the Editor: Tran et al. (Dec. 8 issue)1 describe a remarkable case of a patient with metastatic colorectal cancer treated with autologous T cells specific for mutant KRAS G12D and restricted to the major histocompatibility complex class I allele HLA-C*08:02. The authors hypothesize that in the United States alone, thousands of patients per year may be eligible for T-cell–based immunotherapy targeting KRAS G12D. To estimate how common this opportunity may be, we identified 151 patients with… CONTINUE READING

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