T Cell Receptor Profiling in Type 1 Diabetes

@inproceedings{Jacobsen2017TCR,
  title={T Cell Receptor Profiling in Type 1 Diabetes},
  author={Laura M Jacobsen and Amanda Posgai and Howard R Seay and Michael J Haller and Todd M Brusko},
  booktitle={Current diabetes reports},
  year={2017}
}
PURPOSE OF REVIEW The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual phenotype of autoreactive T cells that mediate β-cell destruction. While autoantibodies provide robust markers of disease progression, early studies tracking autoreactive T cells largely failed to achieve clinical utility. RECENT… CONTINUE READING
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