T Cell Receptor β Chain Lacking the Large Solvent-exposed Cβ FG Loop Supports Normal α/β T Cell Development and Function in Transgenic Mice

Abstract

The striking and unique structural feature of the T cell receptor (TCR) b chain is the bulky solvent-exposed FG loop on the C b domain, the size of almost half an immunoglobulin domain. The location and size of this loop suggested immediately that it could be a crucial structural link between the invariant CD3 subunits and antigen-recognizing a / b chains during TCR signaling. However, functional analysis does not support the above notion, since transgene coding for TCR b chain lacking the complete FG loop supports normal a / b T cell development and function.

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@article{Degermann1999TCR, title={T Cell Receptor β Chain Lacking the Large Solvent-exposed Cβ FG Loop Supports Normal α/β T Cell Development and Function in Transgenic Mice }, author={Sylvie Degermann and Giuseppina Sollami and Klaus Erik Karjalainen}, journal={The Journal of Experimental Medicine}, year={1999}, volume={189}, pages={1679 - 1684} }