T-Cell Epitope Prediction: Rescaling Can Mask Biological Variation between MHC Molecules

@article{MacNamara2009TCellEP,
  title={T-Cell Epitope Prediction: Rescaling Can Mask Biological Variation between MHC Molecules},
  author={Aidan MacNamara and Ulrich D. Kadolsky and Charles R. M. Bangham and Becca Asquith},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={51 - 88}
}
Theoretical methods for predicting CD8+ T-cell epitopes are an important tool in vaccine design and for enhancing our understanding of the cellular immune system. The most popular methods currently available produce binding affinity predictions across a range of MHC molecules. In comparing results between these MHC molecules, it is common practice to apply a normalization procedure known as rescaling, to correct for possible discrepancies between the allelic predictors. Using two of the most… CONTINUE READING