T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity

@article{Verhoef2005TCE,
  title={T Cell Epitope Immunotherapy Induces a CD4+ T Cell Population with Regulatory Activity},
  author={Adrienne Verhoef and Clare T. Alexander and Antony B. Kay and Mark Larch{\'e}},
  journal={PLoS Medicine},
  year={2005},
  volume={2},
  pages={450 - 463}
}
BACKGROUND Synthetic peptides, representing CD4(+) T cell epitopes, derived from the primary sequence of allergen molecules have been used to down-regulate allergic inflammation in sensitised individuals. Treatment of allergic diseases with peptides may offer substantial advantages over treatment with native allergen molecules because of the reduced potential for cross-linking IgE bound to the surface of mast cells and basophils. METHODS AND FINDINGS In this study we address the mechanism of… CONTINUE READING

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Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin

  • JR Lamb, BJ Skidmore, N Green, JM Chiller, M Feldmann
  • J Exp Med
  • 1983
Highly Influential
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