T Cell-Derived IL-10 Determines Leishmaniasis Disease Outcome and Is Suppressed by a Dendritic Cell Based Vaccine

@inproceedings{Schwarz2013TCI,
  title={T Cell-Derived IL-10 Determines Leishmaniasis Disease Outcome and Is Suppressed by a Dendritic Cell Based Vaccine},
  author={Tobias Schwarz and Katharina A. Remer and Wiebke Nahrendorf and Anita Masic and Lisa Siewe and Werner M{\"u}ller and Axel Roers and Heidrun Moll},
  booktitle={PLoS pathogens},
  year={2013}
}
In the murine model of Leishmania major infection, resistance or susceptibility to the parasite has been associated with the development of a Th1 or Th2 type of immune response. Recently, however, the immunosuppressive effects of IL-10 have been ascribed a crucial role in the development of the different clinical correlates of Leishmania infection in humans. Since T cells and professional APC are important cellular sources of IL-10, we compared leishmaniasis disease progression in T cell… CONTINUE READING

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