T-Cell Activation by Recombinant Receptors : CD 28 Costimulation Is Required for Interleukin 2 Secretion and Receptor-mediated T-Cell Proliferation but Does Not Affect Receptor-mediated Target Cell Lysis 1

@inproceedings{Hombach2001TCellAB,
  title={T-Cell Activation by Recombinant Receptors : CD 28 Costimulation Is Required for Interleukin 2 Secretion and Receptor-mediated T-Cell Proliferation but Does Not Affect Receptor-mediated Target Cell Lysis 1},
  author={Andreas A. Hombach and Dagmar Sent and Claudia Schneider and Claudia Heuser and Dimitra Koch and Christoph Pohl and Barbara Seliger and Hinrich Abken},
  year={2001}
}
Recombinant T-cell receptors with antibody-like specificity are successfully used to direct CTLs toward a MHC-independent immune response against target cells. Here we monitored the specific activation of receptor grafted CTLs in the context of CD28 costimulation. Peripheral blood T cells were retrovirally engrafted with recombinant anti-CD30 and anticarcinoembryonic antigen receptors, respectively, that harbor either the FceRI-g or the CD3-z intracellular signaling domain. Cross-linking of… CONTINUE READING

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