T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.

@article{Nakayama1999T786CMI,
  title={T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.},
  author={Masayasu Nakayama and Hirofumi Yasue and Michihiro Yoshimura and Yukio Shimasaki and Kiyotaka Kugiyama and Hisashi Ogawa and Takeshi Motoyama and Yoshihiko Saito and Yasuhiro Ogawa and Yoshihiro Miyamoto and Kazuwa Nakao},
  journal={Circulation},
  year={1999},
  volume={99 22},
  pages={
          2864-70
        }
}
BACKGROUND Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases in general. However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm. METHODS AND RESULTS We searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm. In this study, we demonstrate the existence of 3 linked mutations in the 5'-flanking region of… CONTINUE READING

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