T-705 (favipiravir) inhibition of arenavirus replication in cell culture.

  title={T-705 (favipiravir) inhibition of arenavirus replication in cell culture.},
  author={Michelle Mendenhall and Andrew R. Russell and Terry L. Juelich and Emily L Messina and Donald F. Smee and Alexander N. Freiberg and Michael R. Holbrook and Yousuke Furuta and Juan-Carlos de la Torre and Jack H. Nunberg and Brian B. Gowen},
  journal={Antimicrobial agents and chemotherapy},
  volume={55 2},
A number of New World arenaviruses (Junín [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from mild febrile illness to a severe and often fatal hemorrhagic fever syndrome. These highly pathogenic viruses and the Old World Lassa fever virus pose a significant threat to public health and national security. The only licensed antiviral agent with activity against these viruses, ribavirin, has had mixed success in treating severe arenaviral disease and is… CONTINUE READING


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