T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.

@article{Lewinsky2005T13910DV,
  title={T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.},
  author={Rikke H Lewinsky and Tine G. K. Jensen and Jette M\oller and Allan Stensballe and J\orgen Olsen and Jesper Thorvald Troelsen},
  journal={Human molecular genetics},
  year={2005},
  volume={14 24},
  pages={3945-53}
}
Two phenotypes exist in the human population with regard to expression of lactase in adults. Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH) after weaning. In contrast, lactase-persistent individuals have a high LPH throughout their lifespan. Lactase persistence and non-persistence are associated with a T/C polymorphism at position -13,910 upstream the lactase gene. A nuclear factor… CONTINUE READING
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