T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.

@article{Lewinsky2005T13910DV,
  title={T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.},
  author={Rikke H. Lewinsky and T. G. Jensen and J. M{\o}ller and A. Stensballe and J. Olsen and J. Troelsen},
  journal={Human molecular genetics},
  year={2005},
  volume={14 24},
  pages={
          3945-53
        }
}
  • Rikke H. Lewinsky, T. G. Jensen, +3 authors J. Troelsen
  • Published 2005
  • Medicine, Biology
  • Human molecular genetics
  • Two phenotypes exist in the human population with regard to expression of lactase in adults. Lactase non-persistence (adult-type hypolactasia and lactose intolerance) is characterized by a decline in the expression of lactase-phlorizin hydrolase (LPH) after weaning. In contrast, lactase-persistent individuals have a high LPH throughout their lifespan. Lactase persistence and non-persistence are associated with a T/C polymorphism at position -13,910 upstream the lactase gene. A nuclear factor… CONTINUE READING

    Paper Mentions

    BLOG POST
    −13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1
    • 34
    • Highly Influenced
    A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    • 195
    • PDF
    New insights into the molecular basis of lactase non-persistence/persistence: a brief review.
    • 1
    • Highly Influenced
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES
    The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element.
    • 91
    Identification of a variant associated with adult-type hypolactasia
    • 656
    Adult-type hypolactasia and regulation of lactase expression.
    • 101