T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy.

@article{Stuckey2014TMD,
  title={T₁ mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy.},
  author={Daniel J Stuckey and Sara Jane McSweeney and May Zaw Thin and Josef Habib and Anthony N. Price and Lorna R. Fiedler and Willy Gsell and Sanjay Kumak Prasad and Michael H. Schneider},
  journal={Circulation. Cardiovascular imaging},
  year={2014},
  volume={7 2},
  pages={
          240-9
        }
}
BACKGROUND Diffuse interstitial fibrosis is present in diverse cardiomyopathies and associated with poor prognosis. We investigated whether magnetic resonance imaging-based T1 mapping could quantify the induction and pharmacological suppression of diffuse cardiac fibrosis in murine pressure-overload hypertrophy. METHODS AND RESULTS Mice were subjected to transverse aortic constriction or sham surgery. The angiotensin receptor blocker losartan was given to half the animals. Cine-magnetic… CONTINUE READING
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