T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

@article{Riddell1996TcellMR,
  title={T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients},
  author={S. Riddell and M. Elliott and D. Lewinsohn and M. Gilbert and L. Wilson and S. A. Manley and S. Lupton and R. Overell and T. Reynolds and L. Corey and P. Greenberg},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={216-223}
}
  • S. Riddell, M. Elliott, +8 authors P. Greenberg
  • Published 1996
  • Biology, Medicine
  • Nature Medicine
  • The introduction and expression of genes in somatic cells is an innovative therapy for correcting genetic deficiency diseases and augmenting immune function. A potential obstacle to gene therapy is the elimination of such gene–modified cells by an immune response to novel protein products of the introduced genes. We are conducting an immunotherapy trial in which individuals seropositive for human immunodeficiency virus (HIV) receive CD8+ HIV–specific cytotoxic T cells modified by retroviral… CONTINUE READING
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