T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance

@article{Salmond2009TcellRP,
  title={T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance},
  author={R. Salmond and A. Filby and I. Qureshi and Stefano Caserta and R. Zamoyska},
  journal={Immunological Reviews},
  year={2009},
  volume={228}
}
Summary:  T‐cell development in the thymus and activation of mature T cells in secondary lymphoid organs requires the ability of cells to respond appropriately to environmental signals at multiple stages of their development. The process of thymocyte selection insures a functional T‐cell repertoire, while activation of naive peripheral T cells induces proliferation, gain of effector function, and, ultimately, long‐lived T‐cell memory. The T‐cell immune response is initiated upon engagement of… Expand
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