Systolic Hypertension in the Elderly Program (SHEP): antihypertensive efficacy of chlorthalidone.

@article{Hulley1985SystolicHI,
  title={Systolic Hypertension in the Elderly Program (SHEP): antihypertensive efficacy of chlorthalidone.},
  author={Stephen Benjamin Hulley and Curt D. Furberg and Barry Gurland and Robert H. McDonald and H. Mitchell Perry and H. William Schnaper and James A. Schoenberger and W. McFate Smith and Thomas M. Vogt},
  journal={The American journal of cardiology},
  year={1985},
  volume={56 15},
  pages={913-20}
}
The Systolic Hypertension in the Elderly Program (SHEP) is a randomized, blinded test of the efficacy of antihypertensive drug treatment. In a large feasibility trial, 551 men and women who had isolated systolic hypertension and were at least 60 years old received chlorthalidone (25 to 50 mg/day) or matching placebo as the step I drug. After 1 year, 83% of the chlorthalidone group and 80% of the placebo group were still taking SHEP medications. Of those still taking chlorthalidone, 88% had… CONTINUE READING

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