Systems survey of endocytosis by multiparametric image analysis

@article{Collinet2010SystemsSO,
  title={Systems survey of endocytosis by multiparametric image analysis},
  author={Claudio Collinet and Martin St{\"o}ter and Charles Richard Bradshaw and Nikolay Samusik and Jochen C. Rink and Denise M. Kenski and Bianca H Habermann and Frank Buchholz and Robert Henschel and Matthias S. M{\"u}ller and Wolfgang E. Nagel and Eugenio Fava and Yannis Kalaidzidis and Marino Zerial},
  journal={Nature},
  year={2010},
  volume={464},
  pages={243-249}
}
Endocytosis is a complex process fulfilling many cellular and developmental functions. Understanding how it is regulated and integrated with other cellular processes requires a comprehensive analysis of its molecular constituents and general design principles. Here, we developed a new strategy to phenotypically profile the human genome with respect to transferrin (TF) and epidermal growth factor (EGF) endocytosis by combining RNA interference, automated high-resolution confocal microscopy… CONTINUE READING
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