Systems pharmacology modeling: an approach to improving drug safety.

  title={Systems pharmacology modeling: an approach to improving drug safety.},
  author={Jane P. F. Bai and Robert J Fontana and Nathan D. Price and Vineet Sangar},
  journal={Biopharmaceutics & drug disposition},
  volume={35 1},
Advances in systems biology in conjunction with the expansion in knowledge of drug effects and diseases present an unprecedented opportunity to extend traditional pharmacokinetic and pharmacodynamic modeling/analysis to conduct systems pharmacology modeling. Many drugs that cause liver injury and myopathies have been studied extensively. Mitochondrion-centric systems pharmacology modeling is important since drug toxicity across a large number of pharmacological classes converges to… CONTINUE READING
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