Systems-level overview of host protein phosphorylation during Shigella flexneri infection revealed by phosphoproteomics.

@article{Schmutz2013SystemslevelOO,
  title={Systems-level overview of host protein phosphorylation during Shigella flexneri infection revealed by phosphoproteomics.},
  author={Christoph Schmutz and Erik Ahrn{\'e} and Christoph Alexander Kasper and Therese Tschon and Isabel Sorg and Roland Felix Dreier and Alexander J Schmidt and C{\'e}cile Arrieumerlou},
  journal={Molecular & cellular proteomics : MCP},
  year={2013},
  volume={12 10},
  pages={
          2952-68
        }
}
The enteroinvasive bacterium Shigella flexneri invades the intestinal epithelium of humans. During infection, several injected effector proteins promote bacterial internalization, and interfere with multiple host cell responses. To obtain a systems-level overview of host signaling during infection, we analyzed the global dynamics of protein phosphorylation by liquid chromatography-tandem MS and identified several hundred of proteins undergoing a phosphorylation change during the first hours of… CONTINUE READING
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