Systems-level overview of host protein phosphorylation during Shigella flexneri infection revealed by phosphoproteomics.

  title={Systems-level overview of host protein phosphorylation during Shigella flexneri infection revealed by phosphoproteomics.},
  author={Christoph Schmutz and Erik Ahrn{\'e} and Christoph Alexander Kasper and Therese Tschon and Isabel Sorg and Roland Felix Dreier and Alexander J Schmidt and C{\'e}cile Arrieumerlou},
  journal={Molecular & cellular proteomics : MCP},
  volume={12 10},
The enteroinvasive bacterium Shigella flexneri invades the intestinal epithelium of humans. During infection, several injected effector proteins promote bacterial internalization, and interfere with multiple host cell responses. To obtain a systems-level overview of host signaling during infection, we analyzed the global dynamics of protein phosphorylation by liquid chromatography-tandem MS and identified several hundred of proteins undergoing a phosphorylation change during the first hours of… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Septins and Bacterial Infection

Front. Cell Dev. Biol. • 2016
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 84 references

mTOR signaling at a glance.

Journal of cell science • 2009
View 4 Excerpts
Highly Influenced

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

The Journal of biological chemistry • 2000
View 19 Excerpts
Highly Influenced

The 989 Proteomics Identifications (PRIDE) database and associated tools: status

JA Vizcaíno, RG Côté, A Csordas, JA Dianes, A Fabregat
Nucleic Acids Res 41: • 2013
View 1 Excerpt