Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum.

@article{AmadorNoguez2010SystemslevelMF,
  title={Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum.},
  author={Daniel Amador-Noguez and Xiao-Jiang Feng and Jing Fan and Nathaniel Roquet and Herschel A Rabitz and Joshua D. Rabinowitz},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 17},
  pages={4452-61}
}
Obligatory anaerobic bacteria are major contributors to the overall metabolism of soil and the human gut. The metabolic pathways of these bacteria remain, however, poorly understood. Using isotope tracers, mass spectrometry, and quantitative flux modeling, here we directly map the metabolic pathways of Clostridium acetobutylicum, a soil bacterium whose major fermentation products include the biofuels butanol and hydrogen. While genome annotation suggests the absence of most tricarboxylic acid… CONTINUE READING

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