Systems genetics: From GWAS to disease pathways.

@article{Sijde2014SystemsGF,
  title={Systems genetics: From GWAS to disease pathways.},
  author={Marijke R. van der Sijde and Aylwin C. Y. Ng and Jingyuan Fu},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1842 10},
  pages={
          1903-1909
        }
}
Most common diseases are complex, involving multiple genetic and environmental factors and their interactions. In the past decade, genome-wide association studies (GWAS) have successfully identified thousands of genetic variants underlying susceptibility to complex diseases. However, the results from these studies often do not provide evidence on how the variants affect downstream pathways and lead to the disease. Therefore, in the post-GWAS era the greatest challenge lies in combining GWAS… CONTINUE READING
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