Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.


A grand challenge impeding optimal treatment outcomes for patients with cancer arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental… (More)
DOI: 10.1111/j.1365-2796.2011.02498.x


5 Figures and Tables