Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.

@article{Tian2012SystemsCM,
  title={Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine.},
  author={Qiang Tian and Nathan D. Price and Linda Edwards Hood},
  journal={Journal of internal medicine},
  year={2012},
  volume={271 2},
  pages={111-21}
}
A grand challenge impeding optimal treatment outcomes for patients with cancer arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental principles in biology, and the empowering technologies in genomics, proteomics, single-cell analysis, microfluidics and computational strategies… CONTINUE READING
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References

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Showing 1-10 of 60 references

A CD 133related gene expression signature identifiesanaggressive glioblastomasubtypewith excessive mutations

  • P Picotti, B Bodenmiller, DomonB Mueller LN, R Aebersold
  • ProcNatlAcadSciUSA
  • 2011

A CD133-related gene expression signature identifiesanaggressive glioblastomasubtypewith excessive mutations.ProcNatlAcadSciUSA2011;108:1591–6

  • X Yan, L Ma, D Yi
  • 2011

BRAFmutations in hairycell leukemia

  • E Tiacci, V Trifonov, G Schiavoni
  • NEnglJMed
  • 2011

Biological Complexity Under Attack, A Personal View of Systems Biology and the Coming of ‘‘Big’

  • L. Hood
  • Science. Genetic Engineering&BiotechnologyNews,
  • 2011

Boosting signaltonoise in complexbiology : priorknowledge ispower

  • D Hwang, IY Lee, H Yoo
  • Cell
  • 2011

Cancer geneticsguided discovery of serum biomarker signatures for diagnosis and prognosis of prostatecancer

  • OI Petriv, F Kuchenbauer, AD Delaney
  • ProcNatlAcadSciUSA
  • 2011

Clinical significanceof circulating tumor cells , including cancer stemlike cells , in peripheral blood for recurrence and prognosis in patients with Dukes ’ stageBandCcolorectal cancer

  • PJ Campbell, PJ Stephens, ED Pleasance
  • JClinOncol
  • 2011

Cooperativity within and among Pten , p 53 , andRb pathways induces high - grade astrocytoma inadultbrain

  • LM Chow, R Endersby, X Zhu
  • CancerCell
  • 2011

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