Systems biology of vascular endothelial growth factors.

  title={Systems biology of vascular endothelial growth factors.},
  author={Feilim Mac Gabhann and Aleksander S. Popel},
  volume={15 8},
Several cytokine families have roles in the development, maintenance, and remodeling of the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of the best studied and one of the most complex. Five VEGF ligand genes and five cell-surface receptor genes are known in the human, and each of these may be transcribed as multiple splice isoforms to generate an extensive family of proteins, many of which are subject to further proteolytic processing. Using the VEGF… CONTINUE READING


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