Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.

@article{Mookherjee2009SystemsBE,
  title={Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.},
  author={Neeloffer Mookherjee and Pamela Hamill and Jennifer Gardy and Darren Blimkie and Reza K Falsafi and Avinash Chikatamarla and David J. Arenillas and Silvana C Doria and Tobias Kollmann and Robert E. W. Hancock},
  journal={Molecular bioSystems},
  year={2009},
  volume={5 5},
  pages={483-96}
}
The immune system is very complex, it involves the integrated regulation and expression of hundreds of proteins. To understand in greater detail how the human host defence immunomodulatory peptide LL-37 interacts with innate immunity, a systems approach was pursued. Polychromatic flow cytometry was employed to demonstrate that within human peripheral blood mononuclear cells, CD14+ monocytes, myeloid and plasmocytoid dendritic cells and T- and B-lymphocytes, all responded to LL-37, with the… CONTINUE READING