Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans


A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational… (More)
DOI: 10.1038/ni.1688


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