Systems biology and mode of action based risk assessment.

@article{Edwards2008SystemsBA,
  title={Systems biology and mode of action based risk assessment.},
  author={Stephen W. Edwards and R. Julian Preston},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={106 2},
  pages={312-8}
}
The applications of systems biology approaches have greatly increased in the past decade largely as a consequence of the human genome project and technological advances in genomics and proteomics. Systems approaches have been used in the medical and pharmaceutical realm for diagnostic purposes and target identification. During this same period, the use of mode of action (MOA) for risk assessment has been increasing and there is a need for quantitative risk assessments on an ever-growing number… CONTINUE READING

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