Systems biology: When it is time to die

@article{Bastiaens2009SystemsBW,
  title={Systems biology: When it is time to die},
  author={Philippe I H Bastiaens},
  journal={Nature},
  year={2009},
  volume={459},
  pages={334-335}
}
Any cell biologist can tell you that individual cells from a clonal cell population respond differently to the same stimulus, some not responding at all. In such cases the percentage of responders is seen as a measure of the experimenter’s control over parameters that affect the stimulus, such as uniformity of the cellular environment. Variability in cell response can have grave implications. For instance, some tumour cells refuse to die in response to drugs that trigger programmed cell death… CONTINUE READING

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