Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.

@article{Rooney2009SystemsBM,
  title={Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.},
  author={John Paul Rooney and Ajish George and Ashish Patil and Ulrike Begley and Erin E Bessette and Maria Zappal{\`a} and Xin Huang and Douglas S. Conklin and Richard P. Cunningham and Thomas J. Begley},
  journal={Genomics},
  year={2009},
  volume={93 1},
  pages={42-51}
}
The identification of cellular responses to damage can promote mechanistic insight into stress signalling. We have screened a library of 3968 Escherichia coli gene-deletion mutants to identify 99 gene products that modulate the toxicity of the alkylating agent methyl methanesulfonate (MMS). We have developed an ontology mapping approach to identify functional categories over-represented with MMS-toxicity modulating proteins and demonstrate that, in addition to DNA re-synthesis (replication… CONTINUE READING
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