Systems-based discovery advances drug development.

  title={Systems-based discovery advances drug development.},
  author={Scott A. Waldman and Andre Terzic},
  journal={Clinical pharmacology and therapeutics},
  volume={93 4},
Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free… CONTINUE READING