Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators.

@article{Serhan2008SystemsAW,
  title={Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators.},
  author={Charles Nicholas Serhan},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2008},
  volume={79 3-5},
  pages={
          157-63
        }
}
Using a systems approach to mine spontaneously resolving inflammatory exudates, novel families of lipid- derived mediators were identified in animal systems that control both the duration and magnitude of acute inflammation. These new families were coined with the resolvins and protectins because they possess potent bioactions and novel chemical structures. The mapping of these new resolution circuits has already provided new avenues for appreciating the molecular basis of many inflammatory… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet.

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lipid Mediators in Inflammation.

Lipoxins: nature’s way to resolve inflammation

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 99 REFERENCES

R

  • N. A. Petasis
  • Keledjian, Y.-P. Sun, et al., Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties, Bioorg. Med. Chem. Lett.
  • 2008

Resolving inflammation: pro-resolving lipid mediators and their potential therapeutic impact

  • C. N. Serhan, N. Chiang, T. E. Van Dyke
  • Nat. Rev. Immunol. 8
  • 2008

C

  • K. M. Connor, J. P. SanGiovanni
  • Lofqvist, et al., Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis, Nat. Med. 13
  • 2007

E

  • H. Hasturk, A. Kantarci
  • Goguet-Surmenian, et al., Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo, J. Immunol. 179
  • 2007

J

  • Y. P. Sun, S. F. Oh
  • Uddin, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation, J. Biol. Chem. 282
  • 2007
VIEW 1 EXCERPT