Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation

@inproceedings{Yang2014SystemsAO,
  title={Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation},
  author={Chih-Cheng Yang and Alicia S. Chung and Chia-Yu Ku and Laurence M. Brill and Roy M Williams and Dieter A. Wolf and Philip D. Anderson and Kemal Sami Korkmaz},
  booktitle={F1000Research},
  year={2014}
}
NKX3.1 is a homeobox transcription factor whose function as a prostate tumor suppressor remains insufficiently understood because neither the transcriptional program governed by NKX3.1, nor its interacting proteins have been fully revealed. Using affinity purification and mass spectrometry, we have established an extensive NKX3.1 interactome which contains the DNA repair proteins Ku70, Ku80, and PARP, thus providing a molecular underpinning to previous reports implicating NKX3.1 in DNA repair… CONTINUE READING

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