Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes

@inproceedings{Cook2015SystemsAO,
  title={Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes},
  author={Daniel Cook and Babatunde A. Ogunnaike and Rajanikanth Vadigepalli},
  booktitle={BMC Systems Biology},
  year={2015}
}
BackgroundA hallmark of chronic liver disease is the impairment of the liver’s innate regenerative ability. In this work we use a computational approach to unravel the principles underlying control of liver repair following an acute physiological challenge. MethodsWe used a mathematical model of inter- and intra-cellular interactions during liver regeneration to infer key molecular factors underlying the dysregulation of multiple regeneration modes, including delayed, suppressed, and enhanced… CONTINUE READING
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