Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

@article{Nwachukwu2017SystemsSB,
  title={Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.},
  author={Jerome C Nwachukwu and Sathish Srinivasan and Nelson E Bruno and Jason Nowak and Nicholas JD Wright and Filippo Minutolo and Erumbi S. Rangarajan and Tina Izard and Xin-Qui Yao and Barry J. Grant and Douglas J Kojetin and Olivier Elemento and John A. Katzenellenbogen and Kendall W Nettles},
  journal={Cell chemical biology},
  year={2017},
  volume={24 1},
  pages={35-45}
}
Environmental estrogens and anti-hormone therapies for breast cancer have diverse tissue- and signaling-pathway-selective outcomes, but how estrogen receptor alpha (ERα) mediates this phenotypic diversity is poorly understood. We implemented a statistical approach to allow unbiased, parallel analyses of multiple crystal structures, and identified subtle perturbations of ERα structure by different synthetic and environmental estrogens. Many of these perturbations were in the sub-Å range, within… CONTINUE READING
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Online_DPI: a web server to calculate the diffraction precision index for a protein structure

  • K.S.D. Kumar, M. Garusran, +5 authors K. Sekar
  • J. Appl. Crystallogr
  • 2015
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