Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine

@article{Zhang2016SystemsPD,
  title={Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine},
  author={Wenjuan Zhang and Qin Tao and Zihu Guo and Yingxue Fu and Xuetong Chen and Piar Ali Shar and Mohamed Shahen and Jinglin Zhu and Jun Xue and Yaofei Bai and Ziyin Wu and Zhen-zhong Wang and Wei Xiao and Yonghua Wang},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Though cardiovascular diseases (CVDs) and gastrointestinal disorders (GIDs) are different diseases associated with different organs, they are highly correlated clinically. [] Key Method Firstly, we identified pairs of genes that are associated with CVDs and GIDs and found that these genes are functionally related. Then, the association between 115 heart meridian (HM) herbs and 163 stomach meridian (SM) herbs and their combination application in Chinese patent medicine was investigated, implying that both…
Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery
TLDR
The systems pharmacology method contributes to understand the complex interactions among biological systems, drugs, and complex diseases from a network perspective and provides a novel approach to promote drug discovery in a precise manner and a systems level, thus facilitating the modernization of TCM.
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer
TLDR
The in vivo experiment demonstrated that oral administration of DSD could significantly inhibit the growth of xenografted gastric cancer on mice, and the network pharmacology and bioinformatics-guided approach is feasible and useful in exploring not only the mechanism of action, but also the “new use” of the old CHM formula.
A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine
TLDR
An integrated systems pharmacology approach is presented for illustrating the molecular correlations between pungent flavored compounds and their holistic efficacy at the special organ level and suggests a novel systematic strategy for rational drug development from pungENT TCMs in treating cardiovascular disease and associated liver diseases.
Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn's Disease
  • Su Yeon SuhW. An
  • Biology
    Evidence-based complementary and alternative medicine : eCAM
  • 2017
TLDR
The results suggest that the anti-inflammatory and repair and immune system enhancing effects of PR might have therapeutic impact on Crohn's disease.
Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer's Disease
TLDR
The results indicated that compounds in ATR interact with multiple targets in a synergetic way, and the anti-inflammatory and immune system enhancing effects of ATR might contribute to its major therapeutic effects on Alzheimer's disease.
Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection
TLDR
DHI exerted comprehensive anti-inflammatory effects on LPS, ox-LDL or cholesterol crystal-induced NF-κB, c-jun and p38 activation, as well as IL-1β, TNF-α, and IL-10 secretion in vascular endothelial cells, providing a new understanding of DHI in clinical application on cardiovascular and cerebrovascular diseases.
Integrated Metabolomics and Network Pharmacology Strategy-Driven Active Traditional Chinese Medicine Ingredients Discovery for the Alleviation of Cisplatin Nephrotoxicity.
Renal injury is the main adverse reaction of cisplatin and many traditional Chinese medicines (TCMs) were proved active against renal toxicity. Here, an integrated metabolomics and network
...
...

References

SHOWING 1-10 OF 140 REFERENCES
Systems Pharmacology Dissecting Holistic Medicine for Treatment of Complex Diseases: An Example Using Cardiocerebrovascular Diseases Treated by TCM
TLDR
For the first time, the feature of the drug-target-pathway-organ-cooperations for treatment of multiple organ diseases in holistic medicine was revealed, facilitating the development of novel treatment paradigm for complex diseases in the future.
A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
TLDR
This study performed a high-throughput in silico screen and obtained a group of compounds from CDF which possess desirable pharmacodynamical and pharmacological characteristics, and proposed a strategy to develop novel TCM candidates at a network pharmacology level.
Effects of natural products on ischemic heart diseases and cardiovascular system.
TLDR
The mechanisms of action and interaction of Traditional Chinese Medicines, and the chemicals they contain remain undetermined in most Chinese traditional medicines, and need to be further elucidated using modem biological tools.
Systems pharmacology in drug discovery and therapeutic insight for herbal medicines
TLDR
The aim of the present work is to highlight the role that the systems pharmacology plays across the traditional herbal medicines discipline, which is exemplified by a case study of botanical drugs applied in the treatment of depression.
Human Phenome based on traditional Chinese medicine--a solution to congenital syndromology.
  • J. Li-Ling
  • Medicine
    The American journal of Chinese medicine
  • 2003
TLDR
The TCM-based Human Phenome may offer a fresh view for genotype-phenotype correlations, insights into genedevelopment mechanisms, as well as potential directions for the development of new treatments.
Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities
TLDR
This review of the herbal and alternative sources of tanshinones, and the pharmacokinetics of selected tansinones, discusses anti-cancer properties and identifies critical issues for future research.
The Potential Benefit of Complementary/Alternative Medicine in Cardiovascular Diseases
TLDR
In recent years, more and more clinicians have successfully applied complementary/alternative medicine (CAM) in CVDs prevention and treatment based on standardized conventional therapy, but the role of CAM still needs more clinical evidence and definite mechanism of actions.
HIT: linking herbal active ingredients to targets
TLDR
A comprehensive and fully curated database for Herb Ingredients’ Targets (HIT) has been constructed to complement above resources and contains 5208 entries about 1301 known protein targets affected by 586 herbal compounds from more than 1300 reputable Chinese herbs.
...
...