Systems-Level Analysis of ErbB4 Signaling in Breast Cancer: A Laboratory to Clinical Perspective

@article{Chuu2008SystemsLevelAO,
  title={Systems-Level Analysis of ErbB4 Signaling in Breast Cancer: A Laboratory to Clinical Perspective},
  author={Chih-Pin Chuu and Rou-Yu Chen and John L. Barkinge and Mark F. Ciaccio and Richard Baker Jones},
  journal={Molecular Cancer Research},
  year={2008},
  volume={6},
  pages={885 - 891}
}
Although expression of the ErbB4 receptor tyrosine kinase in breast cancer is generally regarded as a marker for favorable patient prognosis, controversial exceptions have been reported. Alternative splicing of ErbB4 pre-mRNAs results in the expression of distinct receptor isoforms with differential susceptibility to enzymatic cleavage and different downstream signaling protein recruitment potential that could affect tumor progression in different ways. ErbB4 protein expression from… 
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