Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

@inproceedings{Chatterjee2010SystemsBO,
  title={Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood},
  author={Manash S. Chatterjee and William S. Denney and Huiyan Jing and Scott L. Diamond},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time (T(i)) of 1 to 2 hours (depending on donor), while activation of platelets with the GPVI-activator convulxin reduces T(i) to ∼20 minutes. Since current kinetic models fail to generate thrombin in the absence of… CONTINUE READING

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