Systems Biology and New Technologies Enable Predictive and Preventative Medicine

  title={Systems Biology and New Technologies Enable Predictive and Preventative Medicine},
  author={Leroy E. Hood and James R. Heath and Michael E. Phelps and Biaoyang Lin},
  pages={640 - 643}
Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood. Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine. 

Systems Approach to Studying Disease

The ability to detect disease-related perturbations in individual patients will transform health care over the next decade from the authors' current reactive medicine to a new medical practice that is predictive, personalized, preventive, and participatory (P4 medicine).

Network Medicine: Finding the Links to Personalized Therapy

Network medicine is a new approach that focuses on applying systems biology to pharmacology by “understanding the molecular system [and its perturbations] as a whole” so as to unravel the complex

Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive , Personalized , Preventive and Participatory ( P 4 ) Medicine

It is predicted that emerging technologies, together with the systems approaches to diagnosis, therapy and prevention will lead to a down turn in the escalating costs of healthcare.

Systems Biology Meets Functional Medicine.

  • J. Bland
  • Medicine
    Integrative medicine
  • 2019
The Functional Medicine model provides a system that effectively translates the emerging understanding of the gene-environment regulation of the structure and function of the individual into clinical practice.

Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive, Personalized, Preventive and Participatory (P4) Medicine

It is predicted that emerging technologies, together with the systems approaches to diagnosis, therapy and prevention will lead to a down turn in the escalating costs of healthcare.

Systems Biology: a new hope for drug discovery?

  • A. Henney
  • Biology
    Expert opinion on drug discovery
  • 2006
The rapid expansion of biomedical information following the mapping of the human genome has contributed to significant advances in acquiring a highly detailed picture of disease mechanisms at the molecular level, but the return in terms of delivery of new medicines has been relatively modest.

Network systems biology for targeted cancer therapies

From biological network modeling to structural/dynamic network analysis, network systems biology provides unique insight into the potential mechanisms underlying the growth and progression of cancer cells.

Systems pharmacogenomics in the area of personalized medicine

The new era in systems pharmacology has revolutionized the human biology. Its applicability, precise treatment, adequate response and safety measures fit into all the paradigm of medical/clinical

A systems approach to blood disorders.

  • P. Qasba
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2014
Hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programming and reprogramming that are influenced every day by the most mature and understood regulatory networks.

System pharmacogenomics application in infectious diseases

This article details some of the infectious disease pharmacogenomics to the developments in this area and some regulatory issues that need to be addressed.



Systems Biology: A Brief Overview

To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism.

Molecular Imaging: Looking at Problems, Seeing Solutions

Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease and promise to play increasingly important roles in disease diagnosis and therapy.

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network.

An integrated approach to build, test, and refine a model of a cellular pathway, in which perturbations to critical pathway components are analyzed using DNA microarrays, quantitative proteomics, and databases of known physical interactions, suggests hypotheses about the regulation of galactose utilization and physical interactions between this and a variety of other metabolic pathways.

Gene Expression Signatures, Cancer Cell Evolution and Metastatic Progression

Global gene expression profiling and molecular cytogenetics for single cells provide new opportunities to resolve important questions, such as the mechanisms of tumor cell selection during cancer progression, that suggest dissemination is a very early event in the genetic development of human cancers.

Regulatory gene networks and the properties of the developmental process

Although network analysis is yet in its early stages, some fundamental commonalities are already emerging, such as the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes.

Point: Proteomic patterns in biological fluids: do they represent the future of cancer diagnostics?

The recent publication of three reports, from two different research groups, on the use of SELDI-TOF technology in the diagnosis of prostate cancer allows for comparison of the data and the methodology and for the presentation of some important questions that have not been adequately addressed.

A Genomic Regulatory Network for Development

A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here and reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Laser capture microdissection and proteomics: Possibilities and limitation

Progress made to date in the analysis of proteins in LCM‐captured material is reviewed and the scope and limitations of this approach are evaluated.

Molecular imaging of gene therapy for cancer

This review provides descriptions of modalities applicable to imaging different parameters of vector-mediated gene expression in tumors and stem cell tracking in vivo.