Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers

@inproceedings{Zhou2011SystemsBM,
  title={Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers},
  author={Jian-ping Zhou and Xin Mao Chen and Shan Feng and Shi-dong Luo and You-Li Pan and Lei Zhong and Pan Ji and Ze-rong Wang and Shuang Ma and Lin-Li Li and Yu-Quan Wei and Shengyong Yang},
  booktitle={PloS one},
  year={2011}
}
Despite many evidences supporting the concept of "oncogene addiction" and many hypotheses rationalizing it, there is still a lack of detailed understanding to the precise molecular mechanism underlying oncogene addiction. In this account, we developed a mathematic model of epidermal growth factor receptor (EGFR) associated signaling network, which involves EGFR-driving proliferation/pro-survival signaling pathways Ras/extracellular-signal-regulated kinase (ERK) and phosphoinositol-3 kinase… CONTINUE READING

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