Systems Biology: A Brief Overview

  title={Systems Biology: A Brief Overview},
  author={Hiroaki Kitano},
  pages={1662 - 1664}
  • H. Kitano
  • Published 1 March 2002
  • Biology, Medicine
  • Science
To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicine. However, many breakthroughs in experimental devices, advanced software, and analytical methods are required before the achievements of systems biology… 
Analyzing the Biology on the System Level
  • W. Tong
  • Computer Science, Medicine
    Genomics, proteomics & bioinformatics
  • 2004
This review discusses the object, its characteristics, and research attentions in systems biology, and summarizes the analysis methods, experimental technologies, research developments, and so on in the four key fields of systems biology—systemic structures, dynamics, control methods, and design principles.
Scientific Challenges in Systems Biology
It is argued that understanding the robustness of biological systems and the principles behind such phenomena is critically important for establishing the theoretical foundation of systems biology.
Systems cell biology
Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling with an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.
Systems biology--an engineering perspective.
Some of the contributions to systems biology, ranging from modeling approaches to model analysis with a special focus on technique which have not yet been substantially exploited but can be potentially useful in the analysis of biochemical systems are reviewed.
From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity
Systems Biology represents a new paradigm aiming at a whole organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component
Systems Biology-an interdisciplinary approach.
System-level understanding of native biological and pathological systems is needed to provide potential therapeutic targets and robustness in biology, metabolic engineering and idiotypic networks are discussed in the framework of Systems Biology.
Computational systems biology
The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation.
Introduction: a practical guide to the systems approach in biology.
  • I. Maly
  • Medicine
    Methods in molecular biology
  • 2009
The systems approach is defined, and a generic recipe for employing it in biomedical research is offered, and an outlook on the development of systems biology is given.
A reductionist's systems biology: opinion.
  • P. Sorger
  • Biology, Medicine
    Current opinion in cell biology
  • 2005
The field of reaction engineering suggests a reductionist approach to systems biology that fits easily within existing molecular paradigms but that can nonetheless be integrated into expansive physiological perspectives through the use of multi-scale modeling.
Microfluidics technology for systems biology research.
This chapter discusses how a systems biology laboratory can apply microfluidics technology to acquire comprehensive, systematic, and quantitative data for their modeling needs.


Foundations of systems biology
This work aims at system-level understanding at the system level biological systems that are composed of components revealed by molecular biology.
Cybernetics, or Control and Communication in the Animal and the Machine.
This is an extremely thought-provoking book, by the professor of mathematics of the Masachusetts Institute of Technology. The subject matter ranges from mathematical calculators to the nerves and
Nature Biotechnol
  • Nature Biotechnol
  • 2001
Mol. Biol. Cell
  • Mol. Biol. Cell
  • 2000
Nucleic Acids Res
  • Nucleic Acids Res
  • 2000
Additional information can be obtained at http
  • Nature Biotechnol
  • 1999
J. Theor. Biol
  • J. Theor. Biol
  • 1998
Alliance for Cellular Signaling
  • Alliance for Cellular Signaling