Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.

@article{Kweon2000SystemicallyDL,
  title={Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.},
  author={M N Kweon and Masahiro Yamamoto and Masahiro Kajiki and Ichiro Takahashi and Hiroshi Kiyono},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 2},
  pages={199-206}
}
Systemically primed BALB/c mice developed severe diarrhea after repeated oral administration of ovalbumin (OVA). Histological analysis demonstrated that dramatic infiltration of eosinophils and mast cells occurred in the large intestine but not in the small intestine of mice with diarrhea. Interestingly, CD4(+) alphabeta T cells of the large intestine secreted IL-4 and IL-13 at high levels. Identically treated STAT6 gene-disrupted mice failed to develop OVA-induced diarrhea. Further, treatment… CONTINUE READING

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