Systemic treatment for hepatocellular carcinoma: Still unmet expectations

  title={Systemic treatment for hepatocellular carcinoma: Still unmet expectations},
  author={Dimitrios N. Samonakis and Elias Kouroumalis},
  booktitle={World journal of hepatology},
Many patients with hepatocellular carcinoma (HCC) are diagnosed in an advanced stage, so they cannot be offered the option of curative treatments. The results of systemic chemotherapy are unsatisfactory and this has led to molecular targeted approaches. HCC develops in chronically damaged tissue due to cirrhosis in most patients. Several different cell types and molecules constitute a unique microenvironment in the liver, which has significant implications in tumor development and invasion… CONTINUE READING

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