Systemic therapy for metastatic colorectal cancer: current options, current evidence.

@article{Kelly2005SystemicTF,
  title={Systemic therapy for metastatic colorectal cancer: current options, current evidence.},
  author={Hanna L Kelly and Richard M. Goldberg},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 20},
  pages={4553-60}
}
Combination chemotherapy regimens including irinotecan and oxaliplatin markedly improve response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and have supplanted FU/LV as the standard systemic approach for metastatic colorectal cancer. The recent availability of five active chemotherapeutic agents has doubled the median overall survival for metastatic colorectal cancer from 10 to 20 months, and though the optimal strategy for incorporation of all drugs is still… CONTINUE READING
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